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NYU College of Dentistry: Microbiome and Nanoparticle Discoveries Hold Promise for Treating Gut Pain
Abdominal pain is a hallmark of many digestive disorders, including inflammatory bowel disease and irritable bowel syndrome. In an effort to develop targeted treatments for gut pain, NYU researchers and their collaborators have discovered a new enzyme in gut bacteria and are using nanoparticles to deliver drugs inside cells.
Currently, there are no treatments specifically for gut pain, and existing painkillers are often insufficient at managing symptoms. These drugs — including opioids, NSAIDs, and steroids — also come with side effects, some of which directly harm the digestive system. In two new studies, researchers focused on PAR2, a receptor involved in pain signaling that has been shown to play a role in gastrointestinal diseases marked by inflammation and pain. “In focusing on this receptor, we’ve mapped out a pathway between a bacterial enzyme and pain and determined how to block PAR2 using nanoparticles—both of which may help us to treat pain related to digestive disorders in the future,” said Nigel Bunnett, professor and chair of the Department of Molecular Pathobiology at NYU Dentistry and a faculty member in the NYU Pain Research Center. Read more. |